Developing Brains at KI
5th annual edition of the doctoral course Developing Brains is held next week, culminating in a conference September 6th at Nobel Forum with talks given by leading scientist in the field of neural development. Organized by Hjerling-Leffler J, Marklund U, Castelo-Branco G and Lallemend F.

Recent publication in Cell Reports
Diversity of Interneurons in the Dorsal Striatum Revealed by Single-Cell RNA Sequencing and PatchSeq.
Muñoz-Manchado AB, Bengtsson Gonzales C, Zeisel A, Munguba H, Bekkouche B, Skene NG, Lönnerberg P, Ryge J, Harris KD, Linnarsson S, Hjerling-Leffler J.

Recent publication in Cell
Molecular Architecture of the Mouse Nervous System.
Zeisel A, Hochgerner H, Lönnerberg P, Johnsson A, Memic F, van der Zwan J, Häring M, Braun E, Borm LE, La Manno G, Codeluppi S, Furlan A, Lee K, Skene N, Harris KD, Hjerling-Leffler J, Arenas E, Ernfors P, Marklund U, Linnarsson S. KI press release

Recent publication in Developmental Cell
Transcriptional Convergence of Oligodendrocyte Lineage Progenitors during Development.
Marques S, van Bruggen D, Vanichkina DP, Floriddia EM, Munguba H, Väremo L, Giacomello S, Falcão AM, Meijer M, Björklund ÅK, Hjerling-Leffler J, Taft RJ, Castelo-Branco G. KI press release

GRC Hong Kong
Jens Hjerling-Leffler is giving a talk titled "Transcriptional Identification of Brain Cell Types and the Analysis of Disease" at Gordon Research Conference - Molecular and Cellular Neurobiology at The Hong Kong University of Science and Technology, China.

Recent publication in Nature Genetics
Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence.
Savage JE et al (including Skene NG, Muñoz-Manchado AB, Hjerling-Leffler J from the lab).

Recent publication in Nature Genetics
Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.
Nagel M, Jansen PR, Stringer S, Watanabe K, de Leeuw CA, Bryois J, Savage JE, Hammerschlag AR, Skene NG, Muñoz-Manchado AB; 23andMe Research Team, White T, Tiemeier H, Linnarsson S, Hjerling-Leffler J, Polderman TJC, Sullivan PF, van der Sluis S, Posthuma D.

GRC New Hampshire
Jens Hjerling-Leffler is giving a talk titled "Single-Cell Transcriptomics and the Study of the Brain" at Gordon Research Conference - Cell biology of the Neuron in Waterville Valley, New Hampshire, USA.

Recent publication in PLoS Biology
Classes and continua of hippocampal CA1 inhibitory neurons revealed by single-cell transcriptomics
Harris KD, Hochgerner H, Skene NG, Magno L, Katona L, Bengtsson Gonzales C, Somogyi P, Kessaris N, Linnarsson S, Hjerling-Leffler J.

Cortical interneurons in health and disease
Jens Hjerling-Leffler is giving a talk at the EMBO workshop about cortical interneurons in health and disease on Mallorca, Spain. Kasra Nikouei will be presenting his poster at session I 2018-06-18 and Hermany Munguba will be presenting his poster at session II 2018-06-20.

Strat Neuro Retreat 2018
Jens Hjerling-Leffler is giving a talk at Strat Neuro Annual Retreat in Sånga-Säby, Stockholm. You can also find Carolina Bengtsson Gonzales presenting her poster at poster session II 2018-05-31.

PGC pathway to drugs
Jens Hjerling-Leffler is giving a talk at the Psychiatric Genomics Consortium's Pathway to Drugs meeting in Lundbeck conference center in Copenhagen, Denmark.

Jens Hjerling-Leffler is giving a talk titled "Schizofreni och hjärnans byggstenar" at Schizofrenidagen in Aula Medica, Karolinska Insitutet campus Solna. If you missed the talk, it will be broadcasted by the Swedish educational broadcasting company (Utbildningsradion) fall 2018.

We are looking for a post doc to join our team
Please see: Single-cell RNA sequencing on novel mouse models of schizophrenia in combination with human genetics to elucidate cell type- and network-specific genetic programs underlying schizophrenia.

Recent publication in Nature Genetics
Genetic identification of brain cell types underlying schizophrenia
Skene NG, Bryois J, Bakken TE, Breen G, Crowley JJ, Gaspar HA, Giusti-Rodriguez P, Hodge RD, Miller JA, Muñoz-Manchado AB, O'Donovan MC, Owen MJ, Pardiñas AF, Ryge J, Walters JTR, Linnarsson S, Lein ES; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Sullivan PF, Hjerling-Leffler J. KI press release

Recent publication in Molecular Psychiatry
Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals
Coleman JRI, Bryois J, Gaspar HA, Jansen PR, Savage JE, Skene N, Plomin R, Muñoz-Manchado AB, Linnarsson S, Crawford G, Hjerling-Leffler J, Sullivan PF, Posthuma D, Breen G.

Recent publication in Journal of Neuroendocrinology
Maternal thyroid hormone is required for parvalbumin neurone development in the anterior hypothalamic area
Harder L, Dudazy‐Gralla S, Müller‐Fielitz H, Hjerling Leffler J, Vennström B, Heuer H, Mittag J.

Visiting NIH
Carolina Bengtsson Gonzales is moving to Chris McBain's lab in NIH nearby Washington D.C., USA for a year of research. We wish her best of luck and we can't wait until she's back in JHL-lab.

Stockholm-Okazaki workshop
Ana Muñoz Manchado is giving a talk titled "Striatal interneuron diversity: the Pthlh population" at the Stockholm-Okazaki workshop
in Scilife lab in Stockholm, January 24th.

Project student
We welcome Amparo Roig Adam as a new project student in the lab during spring semester of 2018. She's visiting from Polytechnic University of Valencia, Spain, where she's a Bachelor's programme student in Biotechnology.

Recent publication in Genome Medicine
Integrated Bayesian analysis of rare exonic variants to identify risk genes for schizophrenia and neurodevelopmental disorders
Nguyen HT, Bryois J, Kim A, Dobbyn A, Huckins LM, Munoz-Manchado AB, Ruderfer DM, Genovese G, Fromer M, Xu X, Pinto D, Linnarsson S, Verhage M, Smit AB, Hjerling-Leffler J, Buxbaum JD, Hultman C, Sklar P, Purcell SM, Lage K, He X, Sullivan PF, Stahl EA.

BREAKING NEWS: Starting grant to Ana Muñoz Manchado
Huge congratulations to Ana Muñoz Manchado for receiving the Swedish Research Council's starting grant to set up her own lab.

Recent publication in Gastroenterology
Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System
Memic F, Knoflach V, Morarach K, Sadler R, Laranjeira C, Hjerling-Leffler J, Sundström E, Pachnis V, Marklund U.

Talks in Shanghai and Tianjin, China
Jens Hjerling Leffler is giving a talk titled “Neuronal cell identity: single-cell analysis of the juvenile telencephalon” at Institute of Neuroscience in Shanghai Wednesday, October 11th and at the 12th Chinese Neuroscience Society Biennial Conference in Tianjin Friday, October 13th.

Nobel Prize comments on live national TV
Jens Hjerling Leffler commenting on the Nobel Prize in Physiology today live on Swedish national TV.

Recent publication in eLIFE
We congratulate Nathan Skene on his publication: A genomic lifespan program that reorganises the young adult brain is targeted in schizophrenia.
Skene NG, Roy M, Grant SG.

Talk at University of Helsinki, Finland
Jens Hjerling Leffler is giving a talk at the Brain & Mind Symposium Friday, September 22nd.

Talk at Instituto de Neurociencias, Alicante, Spain
Jens Hjerling Leffler is giving a talk titled "Single-Cell Transcriptomics in the Study of the Brain" this Friday, September 15th.

Half-time seminar
Carolina Bengtsson Gonzales' half-time seminar today 13:00 at seminar room Marie, campus Solna.

Developing Brains at KI
4th annual edition of the doctoral course Developing Brains is held next week, culminating in a conference September 1st at Nobel Forum with leading scientist in the field of developmental neuroscience. Organized by J Hjerling-Leffler, U Marklund, G Castelo-Branco, S Linnarsson.

Nordic Neuroscience 2017
Jens Hjerling Leffler is giving a talk today titled "Molecular and electrophysiological diversity of telencephalic parvalbumin-expressing interneurons" at Karolinska Institutet Stockholm, Sweden.

Recent publication in Science
MiR-183 cluster scales mechanical pain sensitivity by regulating basal and neuropathic pain genes
Peng C, Li L, Zhang MD, Gonzales CB, Parisien M, Belfer I, Usoskin D, Abdo H, Furlan A, Häring M, Lallemend F, Harkany T, Diatchenko L, Hökfelt T, Hjerling-Leffler J, Ernfors P.

Project student
We welcome Alexandra Kouznetsova as a new project student in the lab. She's a final year Bachelor's programme of Biomedicine student from Karolinska Institutet.

Society for Neuroscience
Ana Muñoz Manchado is giving a talk today at minisymposium "Mammalian Nervous System Cell Types: CNS Diversity Through the Lens of Single-Cell RNA Sequencing (RNA-seq)" at SfN San Diego, USA.

Visiting researcher
We welcome Marina Valenzuela Villatoro from Fernández Chacón lab, University of Seville to the lab.

Review published in Nature Neuroscience
Disentangling neural cell diversity using single-cell transcriptomics
Poulin JF, Tasic B, Hjerling-Leffler J, Trimarchi JM, Awatramani R.

Recent publication in Science
Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system
Marques S, Zeisel A, Codeluppi S, van Bruggen D, Mendanha Falcão A, Xiao L, Li H, Häring M, Hochgerner H, Romanov RA, Gyllborg D, Muñoz-Manchado AB, La Manno G, Lönnerberg P, Floriddia EM, Rezayee F, Ernfors P, Arenas E, Hjerling-Leffler J, Harkany T, Richardson WD, Linnarsson S, Castelo-Branco G.

New Postdoc
We welcome Nathan Skene as a new postdoctoral fellow in the lab.

New Postdoc
We welcome José A. Martínez-López as a new postdoctoral fellow in the lab.

Recent publication in Journal of Chemical Neuroanatomy
BCL11B/CTIP2 is highly expressed in GABAergic interneurons of the mouse somatosensory cortex
Nikouei K, Muñoz-Manchado AB & Hjerling-Leffler J.

Postdoctoral grant
We congratulate Tanja Bhuiyan for receiving the SNSF Early Postdoc Mobility Grant.

New Postdoc
Tanja Bhuiyan joins the lab as a new postdoctoral fellow.

New PhD student
Kasra Nikouei admitted as PhD student in the lab.

Recent paper published in Science
Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq Amit Zeisel and Ana B. Muñoz Manchado et al.
Additional data resources available under tab “Geneuron” above.

We are looking for a post doc to join our team -Position filled-
Please see: In vivo CRISPR system for elucidating the genetic code of adolescent brain maturation

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